Assessing the Benefits and Ethical Risks of Genomic Medicine in Personalized Public Health Care

Yusriani Yusriani; Dinda  Sari; Puput  Mustika

doi:10.71435/595696

Authors

Yusriani Yusriani Universitas Megarezky
Dinda Sari Universitas Megarezky
Puput Mustika Universitas Megarezky

DOI:

https://doi.org/10.71435/595696

Keywords:

Genomic Medicine, Public Health, Personalized Treatment

Abstract

Genomic medicine which leverages the insights gained from the human genome, holds transformative potential in public health by enabling personalized treatment strategies, improving disease prevention, and enhancing healthcare outcomes. This literature review examines both the benefits and risks associated with the application of genomic medicine in public health. The benefits include more accurate disease diagnoses through genetic profiling, targeted therapies for conditions like cancer and cardiovascular diseases, and improved preventive care by identifying genetic predispositions to various health conditions. These advances offer the potential for better health outcomes and cost-effective care through early interventions. However, the integration of genomic medicine into public health systems presents several risks, including ethical concerns related to privacy, genetic discrimination, and the protection of sensitive genetic data. The economic challenges associated with the implementation of genomic medicine, such as high costs and potential inequities in access, are also discussed. Additionally, the scientific uncertainty surrounding the interpretation of certain genetic variations poses challenges in clinical applications. This review highlights the need for strong policies and ethical frameworks to ensure the responsible use of genomic data while promoting equitable access to genomic technologies across diverse populations. In conclusion, while genomic medicine holds significant promise, its integration into public health systems requires careful consideration of these risks to maximize its benefits and ensure fairness in access.

References

Ahmed, Z., Zeeshan, S., Mendhe, D., & Dong, X. (2020). Human gene and disease associations for clinical‐genomics and precision medicine research. Clinical and translational medicine, 10(1), 297-318. https://doi.org/10.1002/ctm2.28

Baverstock, K. (2021). The gene: an appraisal. Progress in Biophysics and Molecular Biology, 164, 46-62. https://doi.org/10.1016/j.pbiomolbio.2021.04.005

Cohen, I. G., Farahany, N. A., Greely, H. T., & Shachar, C. (Eds.). (2021). Consumer genetic technologies: ethical and legal considerations. Cambridge University Press.

Dunbar, A., Bolton, K. L., Devlin, S. M., Sanchez-Vega, F., Gao, J., Mones, J. V., ... & Mantha, S. (2021). Genomic profiling identifies somatic mutations predicting thromboembolic risk in patients with solid tumors. Blood, The Journal of the American Society of Hematology, 137(15), 2103-2113. https://doi.org/10.1182/blood.2020007488

Ifedinezi, O. V., Nnaji, N. D., Anumudu, C. K., Ekwueme, C. T., Uhegwu, C. C., Ihenetu, F. C., ... & Onyeaka, H. (2024). Environmental antimicrobial resistance: implications for food safety and public health. Antibiotics, 13(11), 1087. https://doi.org/10.3390/antibiotics13111087

Khoury, M. J., Bowen, S., Dotson, W. D., Drzymalla, E., Green, R. F., Goldstein, R., ... & Bunnell, R. (2022). Health equity in the implementation of genomics and precision medicine: A public health imperative. Genetics in Medicine, 24(8), 1630-1639.

Khoury, M. J., Bowen, S., Dotson, W. D., Drzymalla, E., Green, R. F., Goldstein, R., ... & Bunnell, R. (2022). Health equity in the implementation of genomics and precision medicine: a public health imperative. Genetics in Medicine, 24(8), 1630-1639. https://doi.org/10.1016/j.gim.2022.04.009

Killer, M., Farrokhseresht, M., & Paterakis, N. G. (2020). Implementation of large-scale Li-ion battery energy storage systems within the EMEA region. Applied energy, 260, 114166. https://doi.org/10.1016/j.apenergy.2019.114166

Lappalainen, T., & MacArthur, D. G. (2021). From variant to function in human disease genetics. Science, 373(6562), 1464-1468. https://doi.org/10.1126/science.abi8207

Maduelosi, B. I. (2024). The impact of clustered regularly interspaced short palindromic repeats (CRISPR) in pharmacy (Master's thesis, University of Malta).

Meyer, E. L., Mesenbrink, P., Dunger-Baldauf, C., Fülle, H. J., Glimm, E., Li, Y., ... & König, F. (2020). The evolution of master protocol clinical trial designs: a systematic literature review. Clinical Therapeutics, 42(7), 1330-1360. https://doi.org/10.1016/j.clinthera.2020.05.010

Munirathnam, R. (2023). Assessing the impact of data science on drug market access and health economics: A comprehensive review. International Journal of Data Analytics (IJDA), 3(1), 36-54.

Ndudi, W., Edo, G. I., Jikah, A. N., Zainulabdeen, K., Mohammed, A. A., John, B. E., ... & Agbo, J. J. (2024). Environmental toxicology in addressing public health challenges in Africa. Ecological Frontiers. https://doi.org/10.1016/j.ecofro.2024.03.006

Parisi, C., & Rodríguez-Cerezo, E. (2021). Current and future market applications of new genomic techniques. Publications Office of the European Union: Luxembourg, JRC123830. https://doi.org/10.1016/j.gim.2022.04.009

Petrovick, M. S., Boettcher, T., Fremont-Smith, P., Peragallo, C., Ricke, D. O., Watkins, J., & Schwoebel, E. (2020). Analysis of complex DNA mixtures using massively parallel sequencing of SNPs with low minor allele frequencies. Forensic Science International: Genetics, 46, 102234. https://doi.org/10.1016/j.fsigen.2020.102234

Sanavia, T., Birolo, G., Montanucci, L., Turina, P., Capriotti, E., & Fariselli, P. (2020). Limitations and challenges in protein stability prediction upon genome variations: towards future applications in precision medicine. Computational and structural biotechnology journal, 18, 1968-1979. https://doi.org/10.1016/j.csbj.2020.07.011

Schloss, J. A., Gibbs, R. A., Makhijani, V. B., & Marziali, A. (2020). Cultivating DNA sequencing technology after the human genome project. Annual review of genomics and human genetics, 21, 117-138. https://doi.org/10.1146/annurev-genom-111919-082433

Strianese, O., Rizzo, F., Ciccarelli, M., Galasso, G., D’Agostino, Y., Salvati, A., ... & Rusciano, M. R. (2020). Precision and personalized medicine: how genomic approach improves the management of cardiovascular and neurodegenerative disease. Genes, 11(7), 747. https://doi.org/10.3390/genes11070747

Sugandh, F. N. U., Chandio, M., Raveena, F. N. U., Kumar, L., Karishma, F. N. U., Khuwaja, S., ... & Sugandh, F. (2023). Advances in the management of diabetes mellitus: a focus on personalized medicine. Cureus, 15(8). https://doi.org/10.7759/cureus.43697

Zhang, L. (2021). “Personal information of privacy nature” under Chinese Civil Code. Computer Law & Security Review, 43, 105637. Zhang, L. (2021). “Personal information of privacy nature” under Chinese Civil Code. Computer Law & Security Review, 43, 105637.